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Mechanical stress can damage the tripeptide (although as a smaller molecule its mechanical sensitivity is lower than that of large peptides)

This structural and pharmacological relationship between MT-II and PT-141 makes them directly comparable research tools for dissecting the contributions of MC1R activation to MT-IIs biological profile , with PT-141 functioning as an MT-II analogue from which the tanning biology has been partially removed while preserving central melanocortin receptor activity

Pemov A, Li H, Presley W, Wallace MR, Miller DT

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